Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility
نویسندگان
چکیده
منابع مشابه
Susceptibility Genes in Hereditary Breast Cancer
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متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولBreast cancer susceptibility and the DNA damage response.
Breast cancer is a disease caused by a complex combination of genetic and environmental factors. It is one of the most common types of cancer affecting women in the Western world. In 2004 in the United States, it is estimated that more than 200,000 new cases of breast cancer will be diagnosed and over 40,000 will die of this disease. Linkage analysis of families with a high risk of breast cance...
متن کاملFANCD2 and DNA Damage
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in ...
متن کاملHeterozygous Mutations in DNA Repair Genes and Hereditary Breast Cancer: A Question of Power
The emerging technology of massively parallel DNA sequencing has had a major impact on progress in genomics and personalized medicine [1]. Most recently, DNA sequencing of whole exomes (complete coding regions of the human genome) has revealed the genetic basis of many previously-not-localized Mendelian traits [2]. In diseases where the underlying genetic basis is more dilute and complex, old c...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-00766-9